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Kidney transplantation remains the preferred treatment for patients with end-stage kidney disease. However, the ongoing shortage of donor organs continues to limit the availability of transplant treatments. Existing evaluation methods, such as the kidney donor profile index (KDPI) and pre-transplant donor biopsy (PTDB), have various limitations, including low discriminative power, invasiveness, and sampling errors, which reduce their effectiveness in organ quality assessment and contribute to the risk of unnecessary organ discard. In this study, we explored the dynamic optical coherence tomography (DOCT) as a label-free, non-invasive approach to monitor the viability ofex vivomouse kidneys during static cold storage over 48 hours. The dynamic metrics logarithmic intensity variance (LIV), early OCT correlation decay speed (OCDS_e), and late OCT correlation decay speed (OCDS_l) were extracted from OCT signal fluctuations to quantify temporal and spatial tissue activity and deterioration. Our results demonstrate that DOCT provides complementary information relevant to tissue viability, in addition to the morphological assessment offered by conventional OCT imaging, showing potential to improve pre-transplant organ evaluation and clinic decision-making. 

ABSTRACT In recent years, numerous flood events have caused loss of life, widespread disruption, and damage across the globe. These devastating impacts highlight the importance of a better understanding of flood generating processes, their impacts, and their variability under climate and landscape changes. Here, we argue that the ability to better model flooding is underpinned by the grand challenge of understanding flood generation mechanisms and potential impacts. To address this challenge, the World Meteorological Organization‐Global Energy and Water Exchanges (GEWEX) Hydrometeorology Panel (GHP) aims to establish a Global Flood Crosscutting project to propagate flood modeling and research knowledge across regions and to synthesize results at the global scale. This paper outlines a framework for understanding the dynamics and impacts of runoff generation processes and a rationale for the role of a Global Flood Crosscutting project to address these challenges. Within this Global Flood Crosscutting project, we will establish a common terminology and methods to enable the global research community to exchange knowledge and experiences, and to design experiments toward developing actionable recommendations for more effective flood management practices and policies for improved resilience. This harmonization of rich perspectives across disciplines will foster the co‐production of knowledge primed to advance flood research, particularly in the current period of heightened climate variability and rapid change. It will create a new transdisciplinary paradigm for flood science, wherein different dimensions of mechanistic understanding and processes are rigorously considered alongside socioeconomic impacts, early warning communications, and longer‐term adaptation to alleviate flood risks in society. 

Visual representations are essential to scientific research and teaching, playing a role in conceptual understanding, knowledge generation, and the communication of discovery and change. Undergraduate students are expected to interpret, use, and create visual representations so they can make their thinking explicit when engaging in discourse with the scientific community. Despite the importance of visualization in the biosciences, students often learn visualization skills in an ad hoc fashion without a clear framework. We used a mixed-methods sequential explanatory study design to explore and assess the pedagogical needs of undergraduate biology students (n = 53), instructors (n = 13), and teaching assistants (n = 8) in visual science communication education. Key themes were identified using inductive grounded theory methods. We found that extrinsic motivations, namely time, financial resources, and grading practices, contribute to a lack of guidance, support, and structure as well as ambiguous expectations and standards perceived by students and instructors. Biology and science visualization instructors cite visual communication assessments as a way of developing and evaluating students’ higher-order thinking skills in addition to their communication competencies. An output of this research, the development of a learning module, the Visual Science Communication Toolkit, is discussed along with design considerations for developing resources for visual science communication education. 

The investigation of gene regulation therapeutics for the treatment of skin‐related diseases is rarely explored in part due to inefficient systemic delivery. In this study, a bottlebrush polymer‐antisense oligonucleotide (ASO) conjugate, termed pacDNA, designed to target IL‐17 receptor A (IL‐17RA), which is involved in psoriasis pathogenesis is presented. Systemic administration of pacDNA led to its accumulation in epidermis, dermis, and hypodermis of mouse skin, reduced IL‐17RA gene expression in skin, and significantly reversed the development of imiquimod (IMQ)‐induced psoriasis in a mouse model. These findings highlight the potential of the pacDNA as a promising nanoconstruct for systemic oligonucleotide delivery to the skin and for treating psoriasis and other skin‐related disorders through systemic administration. 

This perspective summarizes the role of binders in zeolitic catalytic systems and provides insights into how binders affect acid density, porosity, and the control of the proximity between metal and acid sites within shaped zeolite catalysts. 

Abstract Variability of millimeter wavelength continuum emission from Class II protoplanetary disks is extremely rare, and when detected, it is usually interpreted as originating from nonthermal emission mechanisms that relate to the host star itself rather than its disk. During observations made as part of the AGE-PRO Large Program, significant variability in the brightness of the 2MASS J16202863-2442087 system was detected between individual executions. We report the observed properties of the variability detected at millimeter wavelengths and investigate potential driving mechanisms. To investigate the nature of the variability, we construct a light curve from the continuum observations and analyze images constructed from both flaring and quiescent emission. We characterize the dust disk around the star through analysis in the image and visibility plane, and carry out kinematic analysis of CO (2–1) emission from the gas disk. The continuum flux decays by a factor of 8 in less than an hour, and by a factor of 13 within 8 days. The peak brightness coincides with an expected brightness maximum extrapolated from the periodicity of previously observed optical variability. The flare is most likely the product of synchrotron emission in the close vicinity of the star. The nature of the millimeter flare closely resembles those detected in very close binary systems, and may be due to the interaction of magnetic fields in an as-yet undetected binary. Alternatively, if the central host is a single-star object, the flare may be due to the interaction of magnetic field loops at the stellar surface or a strong accretion burst. 

Abstract The ALMA survey of Gas Evolution in PROtoplanetary disks (AGE-PRO) Large Program aims to trace the evolution of gas disk mass and size throughout the lifetime of protoplanetary disks by using the Atacama Large Millimeter/submillimeter Array (ALMA). This paper presents Band-6 ALMA observations of 10 embedded (Class I and Flat Spectrum) sources in the Ophiuchus molecular cloud, with spectral types ranging from M3 to K6 stars, which serve as the evolutionary starting point in the AGE-PRO sample. While we find four nearly edge-on disks (≥70°), and three highly inclined disks (≥60°) in our sample, we show that, as a population, embedded disks in Ophiuchus are not significantly contaminated by more-evolved, but highly inclined sources. We derived dust disk masses from the Band-6 continuum and estimated gas disk masses from the C¹⁸OJ= 2−1 and C¹⁷OJ= 2−1 lines. The mass estimates from the C¹⁷O line are slightly higher, suggesting C¹⁸O emission might be partially optically thick. While the¹²CO and¹³CO lines are severely contaminated by extended emission and self-absorption, the C¹⁸O and C¹⁷O lines are allowed to trace the radial extent of the gaseous disks. From these measurements, we found that the C¹⁸OJ= 2−1 and C¹⁷OJ= 2−1 fluxes correlate well with each other and with the continuum fluxes. Furthermore, the C¹⁸O and C¹⁷O lines present a larger radial extension than disk dust sizes by factors ranging from ∼1.5 to ∼2.5, as is found for Class II disks using the radial extension of the¹²CO. In addition, we have detected outflows in three disks from¹²CO observations. 

Abstract The inward drift of millimeter–centimeter sized pebbles in protoplanetary disks has become an important part of our current theories of planet formation and, more recently, planet composition as well. The gas-to-dust size ratio of protoplanetary disks can provide an important constraint on how pebbles have drifted inward, provided that observational effects, especially resolution, can be accounted for. Here we present a method for fitting beam-convolved models to integrated intensity maps of line emission using theastropyPython package and use it to fit¹²CO moment zero maps of 10 Lupus and 10 Upper Scorpius protoplanetary disks from the ALMA Survey of Gas Evolution of PROtoplanetary Disks (AGE-PRO) Program, a sample of disks around M3-K6 stars that cover the  ∼1–6 Myr of gas disk evolution. From the unconvolved best fit models, we measure the gas disk size ( $R_{\mathrm{CO},90\%}^{\mathrm{model}}$), which we combine with the dust disk size ( $R_{\mathrm{dust},90\%}^{\mathrm{FRANK}}$) from continuum visibility fits from M. Vioque et al. to compute beam-corrected gas-to-dust size ratios. In our sample, we find gas-to-dust size ratios between  ∼1 and  ∼5.5, with a median value of $2.78_{-0.32}^{+0.37}$. Contrary to models of dust evolution that predict an increasing size ratio with time, we find that the younger disks in Lupus have similar (or even larger) median ratios $\left(3.02_{-0.33}^{+0.33}\right)$than the older disks in Upper Sco $\left(2.46_{-0.38}^{+0.53}\right)$. A possible explanation for this discrepancy is that pebble drift is halted in dust traps combined with truncation of the gas disk by external photoevaporation in Upper Sco, although survivorship bias could also play a role.